Juventus moved closer to a sixth straight Italian title as they beat Pescara to go eight points clear.
Gonzalo Higuain scored twice in the first half, taking him to 23 Serie A goals this season.
Juve brought off Paulo Dybala after he was the victim of a late challenge – possibly with Wednesday’s Champions League game at Barcelona in mind.
The Argentine scored twice in Tuesday’s first leg, a 3-0 win, which has put them on the brink of the semi-finals.
Second-placed Roma drew 1-1 with Atalanta, with Edin Dzeko scoring a second-half equaliser, to lose ground on the champions.
Lazio drew 2-2 with Genoa thanks to Luis Alberto’s injury-time equaliser.
Manuel Pasqual scored a stoppage-time winner as Empoli, who are now five points above the relegation zone, beat Fiorentina 2-1 in the Florence derby.
Joao Pedro scored twice as Cagliari thrashed Chievo 4-0.
Torino drew 1-1 with Crotone, while Palermo and Bologna played out a goalless draw.
Earlier in the day, Milan came from 2-0 down to draw 2-2 with Inter thanks to an injury-time Cristian Zapata goal.
