The 62-year-old filmmaker, who succeeds Mexican Director Alejandro Gonzalez Inarritu, will head the panel that will award the 73rd Palme d’Or prize.
“I’m honoured to be the first person of the African diaspora (USA) to be named President of the Cannes Jury and of the main film festival,” Lee said in a statement.
His latest movie “BlacKkKlansman” won the Cannes Grand Prix in 2018.
This year’s Cannes, the biggest gathering of the global movie industry, will run from May 12 till May 23.
Other members of the jury and the films on the programme will be announced mid-April.